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KMID : 0364820180540010018
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Korean Journal of Microbiology
2018 Volume.54 No. 1 p.18 ~ p.23
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Chemical constituents from the culture filtrate of a Himalayan soil fungus, Preussia sp. and their anti-inflammatory activity
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Youn Ui-Joung
Seo Seung-Suk
Yim Joung-Han
Kim Il-Chan
Han Se-Jong
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Abstract
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A new naturally occurring benzoic acid derivative, benzyl 2,4- di(benzyloxy)benzoate (1) and six known compounds (2?7) were isolated from the fungus, Preussia sp. found in frozen soil of the Himalaya Mountain. The structures of the new compound, together with the known compounds were determined by 1Dand 2D-NMR experiments, as well as comparison with published values. In addition, to the best of our knowledge, the known compounds 2?7 were isolated for the first time from the genus Preussia and the family Sporormiaceae. The isolates were evaluated for cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production induced by lipopolysaccharide (LPS) in mouse macrophage RAW 264.7 cells in vitro. Compounds 1 and 2 inhibited NO production by 50.7% and 88.5% at a concentration of 100 mg/ml, respectively.
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KEYWORD
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Preussia sp., Sporormiaceae, benzoic acid derivative, diketopiperazine, nitric oxide
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